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van den Brandt PA, Spiegelman D, Yaun SS, Adami HO, Beeson L, Folsom AR, et al

GLP-1RAs can be categorised based on molecular size, chemical structure and duration of action

For example, sc injection of ghrelin enhances CPP expression for a high fat diet in mice, whereas CPP expression is absent in GHSR KO mice or wildtype mice receiving acute oral gavage of the GHSR antagonist Compound 26 [63]

In addition to needing long-term data in primary CV prevention populations, further research evaluating the CV effects of other GLP-1RA and SGLT2-I is required to understand whether such findings are agent or dose dependent

If you have patients and clients who wonder whether taking the shots might be the right move, first tell them theres a way they can naturally raise their GLP-1 (and GIP)