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Another recent meta-analysis reported no association between GLP-1 agonist use and pancreatic cancer 12

Drug-drug interactions between glucagon-like peptide 1 receptor agonists and oral medications: a systematic review

A related study revealed that the peripheral administration of D-glucose significantly enhances morphine-mediated antinociception, suggesting a synergistic interaction between the glucose and opioid pathways 48

Tirzepatide is not suggested for individuals with a history of pancreatitis or thyroid cancer, as it may increase the risk of these conditions

STZ, streptozotocin