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For individuals with severe or complex obesity (higher BMI and significant health issues), bariatric surgery is often considered the more effective and durable treatment, especially for long-term weight maintenance and disease remission

Antidiabetic agents for treatment of Parkinsons disease: a meta-analysis

however, as noted earlier, findings have not yet been published

For diabetes control: Some women develop gestational diabetes or have type 2 diabetes that needs ongoing management after birth

For example, if GLP-1 activation reduces appetite but also triggers compensatory reductions in metabolic rate, adding glucagon receptor activation that increases energy expenditure counteracts this adaptation