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These drugs may also improve heart health in perimenopausal and menopausal women by lowering blood pressure, reducing LDL cholesterol, and increasing insulin sensitivity, counteracting the increased risk of heart disease that occurs as estrogen levels decline

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Acknowledgements This work was supported by research grants from the National Key Research and Development Program of China (2016YFA0100501), the Chinese National 973 Program (2012CB517502), the National Natural Sciences Foundation of China (81400798, 81400767, 81401142, 81270858, and 81570692), and the Beijing Natural Sciences Foundation of China (7163233)

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