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These findings demonstrate that both basal and agonist-induced GLP-1R phosphorylation are critical for receptor signalling in -cells, revealing a previously unappreciated role for basal phosphorylation in shaping receptor behaviour and establishing a positive link between GLP-1R phosphorylation and -cell signalling competence

Moreover, bD-G1A and tD-G1A exhibited improved in vitro Caco-2 cellular permeability and showed higher in vivo bioavailability (7.58% and 8.63%) after oral administration

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GLP-1s and Hormone Therapy: A New Era in Menopause Metabolic Care

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