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The autzhors searched MEDLINE, Embase, Cochrane Library, Scopus and Web of Science from inception to August 28, 2025 for randomised controlled trials (RCTs), non-randomised interventional studies and observational studies reporting weight outcomes after cessation of GLP-1RAs in adults with overweight or obesity

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When we look at the 2020 to 2025 guidelines, and then we compare that to 2025, moving on to 2030, theres a couple things that I think a lot of people are missing

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Body weight increases most rapidly in the first 3 months after discontinuation, then gradually slows

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