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Pandoras Box: Uncertain Ingredients and Uncontrolled Quality Unlike their FDA-approved counterparts, compounded GLP-1s lack standardized ingredients and rigorous quality control measures

In contrast, a study in APP/PS1 NEFL / mice showed that deletion of the Nefl gene increased neocortical amyloid- (Ab) deposition, synaptic vulnerability and microglia proliferation around Ab plaques, suggesting a protective role for NEFL in AD [9]

This is largely because: Employers have historically been hesitant to classify obesity as a disease state

Even so, treatments have been developed to help overcome insulin resistance, raising the possibility that similar approaches could eventually be created for GLP-1 resistance

The FDA approved it in 2017 for diabetes but not for weight loss