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Protein set analyses found that semaglutide treatment downregulated proteins involved in key biological pathways governing xenobiotic metabolism, fatty acid metabolism and mammalian target of rapamycin complex 1 (MTORC1) signaling, among others (Extended Data Fig

Findings: Between June 19 and Nov 28, 2019, of 1515 adults assessed for eligibility, 961 participants (mean age 580 years [SD 100]

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Increases insulin secretion in the pancreas to aid digestion 2
