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Tirzepatide was FDA-approved for T2D in 2022, and showed impressive weight reductions in subsequent obesity trials

Stopping abruptly often leads to weight regain, so work with your provider on a gradual plan if discontinuation is the goal

Dehydration secondary to reduced fluid intake, nausea, or vomiting may contribute to headache development

Endocrinology 150:580591

The existence of short, curly, thread-like aggregates have been previously observed for multiple proteins, 62,63 and it is likely that these aggregates do not have such a high periodicity of the -structure as the long, rigid fibrils, but they can be rather a chain of -structure-rich oligomers