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Consider behavioural support such as cognitive behavioural therapy (CBT) or structured weight management programmes, which are recommended within NICE obesity guidelines (CG189, PH53) as adjuncts to pharmacological treatment

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Setting a consistent schedule for these injections helps form a routine

doi:10.1038/laban0512-129 pmid:22517091 Bondolfi L, Ermini F, Long JM, Ingram DK, Jucker M (2004) Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice

For instance, microfluidic-fabricated composite NPs co-loaded with a GLP-1 analogue and sitagliptin reduced fasting glucose levels 1.7-fold more effectively than either agent alone in db / db mice, with sustained HbA1c reductions over six weeks [420]