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The primary degradation pathways include: Hydrolysis

These results are the basis for a positioning of the DPP-4 inhibitors as second-line therapy for the treatment of type 2 diabetes, especially, when hypoglycaemia should strictly be avoided (see section below)

1.1%) and pruritus (11.9% vs 1.1%) were more common in once-weekly users than twice daily users

Getty-Kaushik L et al (2006) Glucose-dependent insulinotropic polypeptide modulates adipocyte lipolysis and reesterification