other glp 1 receptor agonists Frontiers GLP-1 receptor agonists and next-generation
Description
Proc Natl Acad Sci U S A 104: 1507515080
In endometrial cancer cells, liraglutide induces an upregulation in progesterone receptor (PGR) mRNA levels, promotes its protein expression, markedly enhances phosphorylated AMPK levels, and downregulates its downstream effector molecule p-P71S6K, ultimately inhibiting cell viability [58]
27 Importantly, GLP-1 action is short-lived, with a half-life of just 12 minutes in the bloodstream under normal physiological conditions, after which it is broken down by the enzyme dipeptidyl peptidase IV (DPP-4), resulting in a loss of its biological activity
The FTPP peptide adipotide research targets this same visceral compartment through entirely different mechanisms, providing additional context for researchers evaluating their options
Time-to-onset analysis of SSIBs associated with GLP-1 RA in the FAERS database
