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Consistently, administration of GCGR antagonists in patients with T2D resulted in decreased glucose levels (35) but also increased body weight providing human support for glucagon receptor agonism (36)

The NICE guidelines for type 2 diabetes management (NG28) recommend regular review of patients on GLP-1 receptor agonists to assess efficacy, tolerability, and the need for ongoing treatment

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After switching from Tirzepatide to Retatrutide, the timeline may vary depending on your starting dose
