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The aim of this trial was to investigate whether a GLP-1 RA as compared with placebo reduces fluid intake in patients with primary polydipsia

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It also enhances cellular insulin sensitivity , aiding glucose metabolism , controlling blood sugar , preventing insulin resistance , and reducing liver fat deposition

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SIRT1 regulates autophagy, and attenuates endoplasmic reticulum (ER) stress to prevent hypothalamic leptin resistance [157], [158], [159]