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Warnings and Precautions 5.1 Risk of Thyroid C-Cell Tumors In rats, tirzepatide caused a dose-dependent and treatment-duration-dependent increase in the incidence of thyroid C-cell tumors (adenomas and carcinomas) in a 2-year study at clinically relevant plasma exposures [see Nonclinical Toxicology (13.1)]

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However, it is important to reach out to a doctor if you notice: Diarrhea that is severe or does not improve after two weeks Symptoms of dehydration, like lightheadedness, very dark urine, or a rapid heartbeat Stool that contains blood or intense stomach pain Unplanned weight loss or weight loss greater than expected Healthcare providers might change the Zepbound dosage, suggest extra care, or look into other possible reasons

The medications recommended starting dosage for weight loss is 2.5 mg once per week, which can subsequently be gradually increased based on individual tolerance

The participants in both trials underwent a lifestyle programme lasting between 12-16 weeks before undergoing fertility treatment while following a very low-calorie diet (1200/day)