glp-1 gip dual agonist GLP1-GIP receptor co-agonists: a promising evolution in the treatment of type 2 diabetes | Acta Diabetologica Spatiotemporal GLP-1 and GIP receptor

The crystal structures of un-acylated liraglutide and semaglutide are almost identical to GLP-1 (97)

Diabetes Care 43 (2), 487493 (2020)

They include well-known brands like Ozempic and Wegovy, which both contain semaglutide, as well as Mounjaro and Zepbound, which contain Tirzepatide

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GLP-1 RAs have been found to improve overall cardiovascular health and reduce major adverse cardiovascular events (MACE) by improving the endothelial function of the vasculature and lowering ANP (atrial natriuretic peptide) production, leading to reduced blood pressure