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In contrast, the ELIXA trial found no reduction in stroke incidence with lixisenatide in patients with acute coronary syndrome, highlighting variability in cerebrovascular outcomes across the class of GLP-1Ras [46]

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Wegovy and Zepbound help the body mobilize and reduce this difficult-to-shed fat, addressing a key challenge of GLP-1 perimenopause weight loss

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Low responders or those at risk for gastrointestinal ADRs (e.g., SPINK1 variants) can be pre-emptively managed with anti-emetics or alternative agents, improving adherence and safety [87,88]