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Further, the CVOTs in general also suggested a potential benefit of GLP-1 RAs on HF, positioning GLP-1 RAs as another advanced option alongside SGLT2 inhibitors in the otherwise sparse treatment armamentarium for especially HFpEF

Duah notes that rapid weight loss can accelerate bone loss, and without enough vitamin D and calcium, the risk of osteoporosis may increase over time

GLP-1 receptor agonists differ with respect to pharmacokinetic properties, duration of action, and clinical effectiveness

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A major contributor was prescription drug spending, which rose 9.4% in 2025, driven in part by growing use of GLP-1 medications, some of which have list prices exceeding $1,000 per month, according to various estimates