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Approaches such as simultaneous low-dose initiation, careful titration, and close monitoring can help manage tolerability concerns and improve adherence to ARNI therapy

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however, causal data are limited, and further longitudinal studies are required.Taken together, obesity represents a major modifiable determinant of pancreatic health, with implications spanning steatosis, inflammatory diseases, and malignancy
95% confidence interval: 3.27, 19.20) was superior to that in overweight/obesity trials (2.23

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