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On a cellular level, the polarization of macrophages has been stimulated by this molecule, shifting them from the inflammatory M1 phenotype to the anti-inflammatory M2 phenotype, which plays a vital role in tissue regeneration as well in reducing inflammation, as they produce cytokines like IL-10 and TGF-[5]

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The expanding role of GLP-1 receptor agonists: metabolic, cardiovascular and anti-inflammatory benefits

patent expires in December 2031, though its already expiring in markets like Canada, China, and Brazil as early as next year