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Most of these are dose-dependent, meaning they are more likely at higher doses and often improve with continued use
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Rationale and protocol of the Dapagliflozin And Prevention of Adverse outcomes in Chronic Kidney Disease (DAPA-CKD) randomized controlled trial
It suggests these medications may be actively, biologically suppressing the skin's own structural maintenance machinery at the same time the body is losing the volume that skin was previously supporting
