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Tests in obese mice indicated the triple agonist was more powerful than dual agonists in correcting obesity and diabetes (Finan, Yang, Ottaway)

Metabolism GLP-1 gets rapidly metabolized in the circulation by dipeptidyl peptidase-4 (DPP-IV), resulting in a short plasma half-life of approximately 2 min [11]

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doi: 10.3389/fendo.2021.721135 [DOI] [PMC free article] [PubMed] [Google Scholar] 14

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