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Limitations of the evidence Weve based this guide heavily on NCT04050670 because its the only clinical trial directly comparing tirzepatide injection sites

Smaller portions, avoiding trigger foods, and staying upright after meals may help

Fatigue: Some individuals may feel more tired than usual during this initial adjustment phase

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This guide breaks down everything you need to consider when selecting your weekly injection day, from the pharmacokinetics that make any day technically equivalent, to the practical lifestyle factors that make certain days dramatically better for certain people