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Magnesium supports over 300 enzymatic reactions, including those involved in glucose metabolism and insulin sensitivityparticularly relevant for patients with type 2 diabetes using GLP-1 therapy

Kuhre RE, Albrechtsen NJW, Deacon CF, Balk-Mller E, Rehfeld JF, Reimann F, Gribble FM, Holst JJ (2016) Peptide production and secretion in GLUTag, NCI-H716 and STC-1 cells: a comparison to native L-cells

Carlat Verdict: To prevent metabolic side effects when beginning an antipsychotic, start with metformin, but consider a GLP-1 RA for patients who have already been on antipsychotics for a while with a BMI 30 kg/m 2 (or 27 kg/m 2 and obesity-related health problems)

Furthermore, these augmented non-responders ultimately attained comparable outcomes to patients who initially responded well to behavioral therapy alone