long term effects of glp-1 agonists GI Adverse Glucagon-Like Peptide-1 Receptor Relative effects of glucagon-like peptide-1

In STEP-4 (NCT03548987), maintenance semaglutide after 20 weeks for another 48 weeks led to a further 7.9% bodyweight loss for a total 17.4% weight loss over the whole trial, whereas those who switched to placebo regained an average 6.9% (total weight loss of 5.0%) [66]

Month 1: Women : 1.5 mg once weekly Men : 1.8 mg once weekly Month 2: Women: 3 mg once weekly (compared to the standard 5 mg) Men : 3.6 mg once weekly (compared to the standard 5 mg) Month 3: Women : 4.5 mg once weekly (instead of the standard 7.5 mg) Men : 5.4 mg once weekly (instead of the standard 7.5 mg) Doses can be gradually increased while remaining below standard titration levels

Indeed, Ex4 suppresses the cocaine-induced dopamine overflow in the NAc (Egecioglu et al., 2013c

Common side effects include nausea, vomiting, diarrhoea, abdominal pain, and reduced appetite, especially when starting or increasing the dose

These symptoms are typically mild to moderate and tend to decrease over time as the body adjusts to the medication