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Nausea, constipation, reflux, appetite changes, and other GLP-1-related effects can still occur

In a canine model, GLP-1 was found to be sufficient in inducing hepatic glucose disposal when delivered in the portal system, but not when delivered into the peripheral circulation [81]

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Which compound has more published research data available?# Tirzepatide has substantially more published research data as of 2026 because it entered clinical development earlier and has a larger completed trial program across the SURPASS and SURMOUNT study families covering type 2 diabetes, obesity, sleep-disordered breathing, and cardiometabolic endpoints

Second, the reduction in fat mass, particularly visceral fat, removes a major source of inflammatory cytokine production