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Given the limited availability of pediatric data for dual and triple agonists, evidence from adult clinical trials was included where relevant to provide mechanistic insights and contextual understanding

NCT06383390: dedicated cardiac effects study A clinical trial specifically designed to study the cardiac effects of retatrutide is registered on ClinicalTrials.gov

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In a public advisory on Wednesday, Health Canada said that as interest grows in GLP-1 products for weight loss, "some people may turn to unauthorized or counterfeit products, which could pose serious health risks because they have not been assessed by Health Canada for safety, effectiveness, or quality." The versions of the medications authorized for use in Canada are semaglutide (Ozempic and Wegovy injections and Rybelsus oral tablets) and tirzepatide (Mounjaro and Zepbound injections)