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For instance, they may occupy compact enzyme cavities typically inaccessible to other peptides or peptidomimetics with a backbone, especially when the precise binding conformation is unknown

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Crude peptide hydrazide, Preparation 39 is purified by RP-HPLC on Waters XSelectCSH C18 10 pm column (10 mm x 250 mm) at ambient temperature with a linear gradient of 20-55% acetonitrile in water over 23 min after 10% acetonitrile in water for the first 3 min and a constant 0.1% TFA for the 28 min of purification

Michael Tsoukas, principal investigator of the study, Investigator in the Metabolic Disorders and Complications Program at The Institute and Associate Professor in the Division of Endocrinology, McGill University Health Centre (MUHC)

LH, progesterone, and TSH can stimulate aldosterone in vitro : a study on normal adrenal cortex and aldosterone producing adenoma