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A recent study treating ex vivo isolated human bronchi with exendin-4 demonstrated a positive GLP-1R immunostaining pattern in key airway structures, including the epithelium, bronchial cilia, mucous glands, inflammatory cells, and the ASM of medium-sized bronchi (Figure 5A)
Key metabolic hormones (including glucagon-like peptide-1 (GLP-1), leptin, ghrelin, and cholecystokinin (CCK) play dual roles: not only regulating hunger and metabolism, but also directly modulating the activity and expression of taste receptors throughout the oral cavity and gastrointestinal tract
The index date was defined as the first prescription of the GLP-1 RAs of interest during the patient selection time window (August 1, 2020 to December 31, 2022)
However, these molecular mechanisms need to be further elucidated (8)
Even with the usual caution around cross-trial comparisons, the top-line performance profile is hard to ignore
