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Several important safety considerations from UK SmPCs include: Pancreatitis risk : Seek immediate medical attention for severe, persistent abdominal pain Gallbladder disease : Including cholelithiasis and cholecystitis Diabetic retinopathy complications : Particularly with semaglutide in those with pre-existing retinopathy Dehydration and acute kidney injury : Possible with severe gastrointestinal side effects Hypoglycaemia : Increased risk when used with insulin or sulfonylureas (dose adjustment of these medications may be needed) Pregnancy/breastfeeding : Weight management GLP-1 agonists (Wegovy, Saxenda) are contraindicated in pregnancy and should be avoided during breastfeeding [5] [2] Regarding mental health specifically, regulatory agencies have scrutinised GLP-1 medications for potential psychiatric adverse effects

Efficacy of metformin therapy in patients with cancer: a meta-analysis of 22 randomised controlled trials

In this study 35 (56%) patients exposed to GLP-1RAs had an increased incidence of RGC as compared to 12 (19%) of the non-users, a finding that persisted after adjustment for confounders