nice tirzepatide NHS England and have approved the use of Tirzepatide, which you may also know as Mounjaro® or 'the weight loss drug', from primary care. You may well hear that is It's out .. NICE TA

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Adding metformin to tirzepatide for weight loss provides several advantages beyond the modest additional weight loss metformin itself produces: Improved insulin sensitivity may help the body metabolize fat more efficiently Reduced hepatic fat can improve metabolic health markers independent of total weight loss Increased natural GLP-1 production amplifies tirzepatide's appetite-suppressing effects Better blood sugar stability reduces cravings and energy crashes The lean mass concern One valid concern with significant weight loss from GLP-1 medications is the loss of lean muscle mass along with fat

Jastreboff et al., NEJM 2022 n=2,539 non-diabetic adults What that means for you That's 17.8 kg you'd weigh 67.2 kg

Ventorp F, Bay-Richter C, Nagendra AS, Janelidze S, Matsson VS, Lipton J, Nordstrm U, Westrin , Brundin P, Brundin L (2017) Exendin-4 treatment improves LPS-induced depressive-like behavior without affecting pro-inflammatory cytokines

this combination has been shown to decrease appetite, blood glucose, and hunger in the hours following a meal with 2-3 eggs