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Description
In a micellar environment GLP-1 assumes a structure with an Nterminal random coil segment and two helical segments separated by a linker region (112)
The pipeline reflects the industry's focus on three goals: longer dosing intervals (every two weeks instead of weekly), oral formulations (to avoid injections), and multi-receptor agonism (to push past the 15% to 17% weight loss ceiling of pure GLP-1 agonists)
Patents And Regulatory Exclusivities On Inhalers For Asthma And COPD, 1986-2020
Mol Pharm (2013) 10(11):39709
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