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Last reviewed: May 14, 2026 Last updated: May 14, 2026 Last reviewed: May 13, 2026 Last updated: May 13, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Tirzepatide accomplishes this without the urinary glucose spillage that defines SGLT2 inhibitor therapy

doi: 10.1016/j.kint.2023.09.029

While sodium-glucose cotransporter 2 (SGLT2) inhibitors remain the first-line therapy in most CKD guidelines, 70 GLP-1 RAs may provide complementary renal and hemodynamic benefits, particularly among patients with obesity or poor glycemic control