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The main exception to this rule is the GLP-1 class (like semaglutide, tirzepatide, or retatrutide), which may be used for longer under proper supervision since the studies and pharmacology support extended duration

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How Omeprazole and GLP-1 Medications Interact Omeprazole reduces stomach acid by blocking proton pumps, while GLP-1 medications like semaglutide slow gastric emptying and reduce appetite signaling in the brain
