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Even more concerning is the rise in severe obesity

(2006) Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass

Richard Frank, MD, MHSA, Chief Medical Officer at Vida Health, spoke to Medical News Today about how orforglipron may expand access to GLP-1s: The choice between a pill and an injectable comes down to patient preference and potency. The injectables are clearly more potent but require a weekly injection

Renal tubular glucagon-like peptide-1 receptor expression is increased in early sepsis but reduced in chronic kidney disease and sepsis-induced kidney injury

This necessitated developing modified GLP-1 agonists resistant to DPP-4 degradation, allowing once-daily or even once-weekly dosing