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Description
When GLP-1 binds to GLP-1R on the surface of -cells, cAMP-dependent PKA is activated and subsequently activates the downstream signal PI3K, which inhibits apoptosis in islet -cells by blocking the expression of the pro-apoptotic protein Bax (Li et al., 2021) (Figure 4)
Amritha CA, Kumaravelu P, Chellathai DD
CaMKK2 is highly enriched in brain neurons and regulates energy metabolism and neuronal processes that underpin higher order functions such as long-term memory, mood, and other affective functions
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The safety profile of microdosing is unknown
[DOI] [PubMed] [Google Scholar] 4.Campbell J.N., Meyer R.A
