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Conversely, for DDES, some comparative evidence suggests that SGLT2 inhibitors may offer a greater risk reduction than GLP-1RAs [127]

Conversely, at current prices, GLP-1 RAs are unlikely to meet the arbitrary AU$28,000 per QALY willingness-to-pay threshold in either the total or secondary prevention population when considering only their benefits on CVD

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9,10 This could be attributed to natriuresis and the improved function of the vascular endothelium facilitated by the release of nitric oxide

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