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Ozempic, which uses the active ingredient semaglutide, was approved in the US for diabetes in 2017 and subsequently in the UK, and its counterpart for weight loss, Wegovy, was approved in the US in 2021

Abbreviations: R, randomized

Consistent with the conclusion that GLP-1 suppression of glucagon secretion does not fully depend on somatostatin, GLP-1 effects on glucagon secretion can be mimicked by forskolin-induced changes in cAMP

In contrast, the pharmacological nanomolar concentrations of GLP-1RAs predominantly activate the cAMP/PKA pathway, potentially explaining their broader therapeutic effects [122]

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