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When administered, these medications work through several mechanisms: Slowing gastric emptying - Food remains in the stomach longer, which can contribute to feelings of fullness Reducing appetite signaling - The medications act on brain regions involved in hunger and satiety Improving insulin secretion - In response to food intake, insulin release becomes more efficient, which is why these medications were originally developed for diabetes Decreasing glucagon secretion - This hormone raises blood sugar, so reducing it helps with glucose control The two primary GLP-1 receptor agonists used for weight loss are: Semaglutide - FDA-approved for weight management under the brand name Wegovy (also sold as Ozempic for diabetes and Rybelsus as an oral diabetes medication)

All groups from our data showed normal variance, and statistical analysis was performed by two-tailed unpaired t -test or by one-way or two-way ANOVA

Your genetic predisposition, measured through the PlexusDx Precision Peptide Genetic Test, helps predict which medication class aligns with your metabolism

Regular blood tests are paramount to accurately determine the medications effectiveness

There is also substantial impact on overall lifespan with an estimated 520 years of life lost for individuals with a BMI 45 [9]