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The SUMMIT trial, involving 731 individuals with HFpEF and obesity followed for a median of 104 weeks, revealed a 38% decrease in the composite endpoint of cardiovascular mortality or heart-failure deterioration events (HR: 0.62, 95%CI: 0.41-0.95, P = 0.026), driven primarily by fewer worsening heart-failure events (8.0% vs

NCT02305381

Over more than 5 years of followup, women showed ~1 kg greater weight loss but no difference in HbA1c reduction

Patients may notice a loss of vision in one eye upon waking in the morning
