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Stevens, Email: [email protected] Supplementary information Supplementary information is available for this paper at 10.1038/s41467-020-14934-5

The dual effect is counterintuitive: Less acetaldehyde (liver-protective less toxic metabolite produced) Higher blood alcohol concentration (risky same drinks leave you more intoxicated) As principal investigator Wajahat Mehal, MD, professor of medicine at Yale, stated: "If these results are reproduced in humans, people using GLP-1 receptor agonists might be drinking an amount of alcohol that does not normally put them above the legal blood alcohol level, but because they are taking this drug, it does." Important caveat: This study was conducted in mice

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When the right key is inserted, a series of activities is unlocked. In this case that key is GLP-1 and the unlocked activities are the release of insulin and the curbing of the production of glucagon

They showed that among patients treated with non-insulin antidiabetic drugs (with the exception of alpha-glucosidase inhibitors), GLP-1 receptor agonists had the lowest risk ratio for lung cancer (0.49, 95% CI: 0.410.59) compared to insulin regardless of histological type, gender, race, or smoking status