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Semaglutide is ideally suited for adults who are obese or overweight , either with a body mass index (BMI) over 30, or a BMI of 2530 and at least one other complication that is related to body weight, such as insulin resistance, glucose intolerance, type 2 diabetes, high blood pressure, high cholesterol, hypertension, sleep apnea, arthritis, or cardiovascular disease

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It is a novel peptide with triple hormone receptor agonist activity, targeting the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors

On the other hand, researchers have claimed that given the cost of these drugs, if only 10% of overweight Medicare patients filled branded products, it would cost Medicare $26.8B a year