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By activating GLP-1 receptors, retatrutide is thought to promote insulin secretion, reduce appetite, and slow gastric emptying effects that collectively contribute to improved blood glucose control and reductions in body weight

In men with clinically low testosterone (below 300 ng/dL), restoring testosterone to normal range may enhance weight loss outcomes by preserving lean muscle, improving insulin sensitivity, and supporting metabolic rate during caloric deficit

Am J Physiol Endocrinol Metab (2015) 308(8):E6419

By activating these receptors, semaglutide reduces appetite signals and food cravings
