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The area of white adipocytes was determined using ImageJ software (NIH, Bethesda, MD, USA) by outlining white adipocytes with ellipses
The 1mg cohort was a single-step initiation (dosed at 1mg/week throughout without escalation), and a single 10mg vial covers the entire 10-week 1mg cohort schedule
Hydration Both semaglutide and glycine metabolism require adequate hydration
