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Effect of subcutaneous semaglutide vs placebo as an adjunct to intensive behavioral therapy on body weight in adults with overweight or obesity: the STEP 3 Randomized Clinical Trial

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87,88 There is also evidence that metformin can be beneficial in cases of heart failure by modulating the status of myocardial energy metabolic through its activation of AMPK and controlled regulation of lipid and glucose metabolism in cardiomyocytes

The same thing happens after bariatric surgery or any rapid weight loss