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doi: 10.1111/j.1463-1326.2010.01356.x

Faster decision-making with fewer late-stage failures

The modifications made to human GLP-1 include: Amino acid substitutions that resist DPP-4 enzyme degradation Attachment of fatty acid chains (acylation) as seen in semaglutide and liraglutide Fusion with immunoglobulin fragments (as in dulaglutide) to increase molecular size These changes are designed using rational drug design principles and implemented through biotechnology

Policy decisions on the reimbursement of tirzepatide in individual countries should be based on health technology assessments integrating long-term efficacy and safety clinical data with country-specific cost-utility analyses comparing tirzepatide with other glucose-lowering medications used in clinical practice

For an individual who experiences morning queasiness, eating a small, protein-rich snacklike a hard-boiled egg or a few almondsbefore having coffee can provide a protective lining for the stomach
