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However, these residues are on the opposite face of the NTD relative to the expected interface of the core domain and therefore may form an interface with another, as yet unidentified, protein

I learned that there seem to be two main ways people who dont meet the FDA criteria are getting the drugs
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Marfella R et al (2022) Does poor glycaemic control affect the immunogenicity of the COVID-19 vaccination in patients with type 2 diabetes: The CAVEAT study
