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Sulfonylureas [35], which lower blood glucose by stimulating insulin secretion, and thiazolidinediones [36], which act as insulin sensitizers by binding to PPAR- receptors, are similarly not commonly associated with intestinal obstruction

It is primarily synthesized in enterochromaffin cells of the gut mucosa located in the stomach, and to a lesser extent in the pineal gland and other tissues [37]
These findings demonstrate that TNC microglia play a crucial role in the central sensitization of CM, and a better understanding of the function of TNC microglia will help us to further understand the pathogenesis of CM

Furthermore, most of the available evidence comes from secondary analyses of diabetes or obesity cohorts, which may not be fully generalizable to patients with established AITD
