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In the body, semaglutide increases insulin, lowers blood sugar, slows digestion, and suppresses appetite to support weight loss and diabetes control.

Patients were stratified according to exposure (n=106,454) or non-exposure (n=317,698) to once-weekly semaglutide, and incidence rates and hazard ratios (HR) of NAION were estimated in a multivariable Cox proportional hazard regression model

The most striking protective effects of SGLT2is were a marked reduction in hospitalization for heart failure and a remarkable reduced progression of chronic kidney disease

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