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Description
GLP-1 drug discovery began with Gila Monster studies, which identified a peptide (extendin-4) in their venom that eventually led to the development of GLP-1 drugs
Results Administration of a single dose of exenatide (study 1) caused a clear increase in GH levels, peaking between 60 and 120 min post-administration
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These results provide new insights into the molecular basis of ligand specificity in class B GPCRs and may facilitate the development of more specific therapeutics.
